The future of aesthetic medicine is already here: from salmon DNA treatments to the new generation of biostimulators. The race for a youthful and fresh appearance has long moved beyond just operating rooms or volume fillers. Today, science offers a winning combination of regenerative medicine and advanced biostimulators that assist in the reconstruction of the skin. We spoke to Dr. Sivan Mercer, Board-certified dermatologist specializing in aesthetic and laser medicine to discover which treatments truly work and can restore quality, firmness, and vitality to the skin. In recent years, the regenerative approach has dominated, focusing on renewal and self-healing to improve tissues and treat both aesthetic and medical issues.
The trendiest treatment in this field today is Rejuran, which enables repair at the cellular level using wild salmon DNA.
Dr. Mercer, what is behind the wild salmon DNA treatment that has become the hottest name in clinics?
This is a completely different approach from traditional aesthetic treatments. Instead of 'filling' or 'adding,' as has been done in most aesthetic treatments to date. The approach here is 'repair at the cellular level.' The treatment is based on polynucleotides, which are natural RNA/DNA molecules extracted from wild salmon. In the field of aesthetics, it is designed to treat a variety of conditions, from fine lines and wrinkles to a general improvement in the texture and appearance of the skin.
Does this have medical importance beyond a glowing appearance?
This is one of the most important uses. The treatment improves skin quality from the inside out. Rejuran treatment can assist in post-inflammatory conditions such as acne scars, surgical scars, and scars from various injuries. Over the past two years, we have seen more and more combat casualties and soldiers looking for solutions for scars, and this is a field where the treatment offers a significant response. Additionally, it offers a dedicated treatment and solution for problems in the eye area, which is considered challenging to treat, and it improves fine lines and skin texture in a way that regular fillers cannot.
What does the treatment protocol look like?
The treatment is performed through targeted injections over about 20 minutes. The change is gradual and cumulative, and is not immediate or artificially dramatic; this is exactly the Korean approach to skincare: patience and graduality. The improvement arrives gradually, working with the body's natural mechanisms rather than against them. The protocol includes three treatments at intervals of three to four weeks, followed by maintenance treatment once every six to 12 months. This is not a 'magic treatment' but an approach that tries to treat skin problems from the root. After three treatments, the skin is in a much better condition than the starting point. The advantage is that we have already built a healthier foundation, which continues to improve after the treatment.
How popular is this treatment?
Not just science, but it is the beauty secret of the red carpet. It seems that Hollywood has already embraced regenerative medicine with full force. Today, even the world's biggest stars are no longer looking for an overly tight or artificial look. Celebrities like Jennifer Aniston, Kim Kardashian, and Miley Cyrus talk openly about a skincare routine based on improving skin quality, aiming to achieve what the industry calls 'gass skin' -- skin that looks so healthy, clean, and hydrated that it glows and reflects light like glass. For them, the ability to stand before 4K cameras when skin texture looks alive and flexible without heavy makeup is critical. This trend, of skin that looks excellent even without makeup, is filtering quickly from the red carpet to us in Israel for anyone who wants a natural and long-term result, which is usually achieved through a clever combination of skin quality treatments and collagen-building biostimulators like Radiesse.
How is Radiesse different from the regular fillers we know, and why is it considered a biostimulator?
Radiesse is a completely different story from regular hyaluronic acid. It is based on calcium, a substance that exists naturally in the body. Its uniqueness lies in the fact that it doesn't just add volume, but it functions as a powerful biostimulator that rouses the body to action. The material works within the skin and signals to fibroblasts, the cells that build tissue, to produce a new and dense network of collagen and elastin. Research shows that Radiesse is capable of encouraging collagen production at a significantly higher level than other treatments, and the result is not just a momentary change but a long-term improvement in the skin structure itself, which becomes thicker, more flexible, and firmer. As a well-established biostimulator, Radiesse delivers exceptional, long-lasting results both in skin texture refinement and anti-aging, as well as in treating post-inflammatory conditions such as acne scarring. Treatment with it is ideal for sagging neck, and even for treating the back of the hand; it grants a sculpted and tight look."
How does it integrate with the Rejuran salmon DNA treatment?
This is exactly where the synergy between treatments is created. Radiesse works in the deep layers to strengthen the tissue and create stable structural support. Conversely, Rejuran works on the upper skin layer and improves the texture, glow, moisture, and delicate texture in areas where Radiesse is less suitable, such as around the eyes. The combination between them allows us to provide a comprehensive response to the aging process and treat both the deep support layers and the external skin quality.
It sounds like aesthetic medicine is getting closer and closer to the realms of wellness and general medicine.
Absolutely. We see a deep conceptual shift here coming from classical medicine. The leading idea is not just to inject an external material that will do the work but to strengthen the body against aging factors and encourage it to heal and renew itself. Just as we adopt an anti-inflammatory diet, sports, and mindfulness to reduce stress and maintain the body, so too do the new treatments operate through mechanisms of calming and rehabilitating the tissues. The goal is to reduce cellular inflammation and encourage natural anti-aging mechanisms. Aesthetic medicine is aligning with the health perception that seeks healing, vitality, and a natural look that radiates from within.
Dr. Sivan Mercer is an expert in dermatology, aesthetics, and lasers, leading the field of treatments that combine advanced technologies and a wellness approach for natural results. The clinic specializes in skin quality treatments and regenerative medicine.
For a consultation, call 054-796-1333
This article was written in cooperation with Dr. Sivan Mercer