An Iranian nuclear scientist was killed in a strike on a building in Tehran on Friday, state Israeli broadcaster KAN and other local media reported.
The Israeli military did not immediately comment on the reports.
The strike happened in the capital's Gisha neighborhood.
Israeli Defense Minister Israel Katz said that he had instructed the military to intensify attacks on "symbols of the regime" in the Iranian capital, aiming to destabilize it.
"We must strike at all the symbols of the regime and the mechanisms of oppression of the population, such as the Basij (militia), and the regime's power base, such as the Revolutionary Guard," Katz said in a statement.
Nearly half of Iranian ballistic missile launchers destroyed
The strike came a day after sources told The Jerusalem Post that the IDF was close to destroying half of Iran’s ballistic missile launchers. Such statistics could be highly significant because there is a likely tipping point around 50-70% damage to Iranian launchers where, even if the Islamic Republic still has 15,000 ballistic missiles left, it will be unable to launch more than 10-30 at a time.
The same day, the White House said on Thursday that President Donald Trump will make a decision on whether the US will get involved in the Israel-Iran conflict in the next two weeks.
Iran's deputy foreign minister warned against any direct US involvement in the conflict between Israel and Iran, saying Iran had "all the necessary options on the table."
Rocket fired from northern Gaza falls in open area
Around the same time the drone strike in Tehran was reported, a rocket was identified crossing from northern Gaza on Friday and fell in an open area near Kibbutz Be'eri, the IDF said.
The military noted that there were no injuries, and sirens were sounded in accordance with protocol.
Yonah Jeremy Bob and Reuters contributed to this report.