At least 16 people were killed and 28 injured in a bus accident on Egypt's Dahab-Nuweibaa road in South Sinai on Wednesday, the health ministry said in a statement.
Israel Police and Magen David Adom are actively trying to determine if any Israelis were injured during the accident, N12 reported.
The area along the Red Sea coast is popular with tourists.
Last month, 15 people were killed and 32 injured in a road accident in Egypt's Ismailia governorate.
This is a developing story.