At least 17 flydubai flights scheduled for Friday between Dubai and Iranian cities including Tehran, Shiraz and Mashhad have been canceled, the Dubai Airports website showed.
A countrywide internet blackout was reported in Iran on Thursday and extended into Friday as authorities moved to curb expanding protests.
Nationwide protests over economic hardships started at the end of December, and have shaken the country.
No reason given for flight disruption from flydubai
A flydubai spokesperson said that flights to Iran on Friday had been canceled and that the airline "will continue to monitor the situation" and revise its flight schedule accordingly, without giving a reason for the disruption.
In addition, Turkish media have said Turkish Airlines canceled 17 flights, Turkey's Ajet canceled six flights and budget carrier Pegasus Airlines canceled flights to Iranian cities on Friday.
At least two flights between Qatar's Doha and Tehran scheduled for Friday were also canceled, Hamad International Airport website showed.