A motorcyclist killed two men in their 40s and severely wounded two after opening fire on them while riding on Route 443 near Modi'in on Wednesday afternoon.
The police have arrested a suspect in their twenties at the scene.
The wounded have been evacuated to Shamir-Asaf Harofeh and Sheba-Tel Hashomer hospitals according to MDA.
Police were called to the scene and began an initial investigation into the circumstances of the incident.
According to the police assessment, this was likely a criminal incident and not a security incident; the incident is still under investigation.
Israel's emergency medical service, Magen David Adom, subsequently responded to the incident as well.
'Paramedics are providing medical treatment at the scene'
"At 2:05 PM, a report was received at MDA's 101 hotline in the Ayalon region about three men who were injured in a violent incident on Highway 443 near the Mevo Modi'im intersection," the MDA spokesperson stated. "MDA medics and paramedics are providing medical treatment at the scene to three injured people in serious condition.