Pope Leo appealed on Saturday for authorities in Iran and Israel to act with "reason" after recent airstrikes and to pursue dialogue.
He told an audience in St. Peter's Basilica he was following the situation with "great concern."
An Israeli woman who was critically wounded by Iranian missiles succumbed to her wounds early Saturday morning, and another two were killed after a direct hit in a residential neighborhood in Israel's central district.
Over 150 Israelis were wounded overall in the Iranian missile barrages, according to official statements from numerous Israeli hospitals.
Most of the wounded were treated at Sheba, Ichilov, Beilinson, Wolfson, Kaplan, and Shamir Medical Centers and hospitals, and at least 29 of them have been released.
Iran launched over dozens of missiles at Israel
Sirens sounded across Israel following the launch of approximately 150 Iranian missiles and after the IDF had sent an initial warning on Friday to civilians to take shelter as Iranian missiles made their way to Israeli territory.
Initial defense assessments indicate that Iran has fired at least dozens of missiles toward Israeli territory.